SPECT/CT同机融合显像在口腔鳞癌前哨淋巴结定位中的应用

The application of SPECT / CT Co-registration Fusion Scintigraphy in Sentinel Lymph Node Localization in cN0 Oral Squamous Cell Carcinoma

目的探索一种准确、实用的口腔鳞癌前哨淋巴结定位方法。方法术前运用SPECT/CT同机融合显像技术对30例c N0期口腔鳞癌患者的SLN进行定位,术中对定位的SLN活检,术后比较SLN与颈淋巴清扫的病理结果。结果全组病例中,SPECT/CT同机融合图像对SLN定位的准确度为100%,8例患者的前哨淋巴结和颈清扫淋巴结病理结果证实有癌转移,前哨淋巴结活检对颈部淋巴结转移状况评价的敏感度、特异度和准确度均为100%。结论 SPECT/CT同机融合显像技术可以在术前准确定位前哨淋巴结,客观评价c N0期口腔鳞癌患者颈部淋巴结的真实状况。

Objective To explore an accurate and available method in sentinel lymph node localization in cN0 oral squamous cell carcinoma. Methods Preoperative sentinel lymph node localization by SPECT/CT Co-registration Fusion Scintigraphy and intraopera- tive sentinel lymph node biopsy was performed to evaluate the cervical lymph node status in 30 cases of cN0 oral squamous cell carcino- ma and the pathological results of SLN and neck dissection were compared after the operation. Results Among all the 30 cases,the ac- curacy rating of sentinel lymph node localization by SPECT/CT Co-registration Fusion Scintigraphy was 100% . Sentinel lymph nodes were found with metastasis in 8 cases. No non-sentinel lymph node was found with metastasis while sentinel lymph nodes were pathologi- cally negative. The sensitivity, specificity and accuracy of evaluation of neck lymph node metastasis were 100%. Conclusions Preoper- ative SPECT/CT Co-registration Fusion Scintigraphy can be used to locate sentinel lymph node and accurately evaluate the statue of cer- vical lymph node metastasis in cN0 oral squamous cell carcinoma.