摘要
外伤性视神经损伤是由外伤直接或间接导致的视神经损伤,也是颅脑外伤严重的并发症之一,其预后不良,常遗留永久性视力损害。目前视神经的损伤及再生是神经生物学方面的研究热点,因此建立理想的实验动物模型是开发视神经损伤治疗的重要方面。本文就各种大鼠的外伤性视神经损伤模型的造模方法、模型的临床相似性及其利弊进行综述,为进一步的实验研究提供参考。
Traumatic optic nerve injury （ TON） is caused by direct or indirect optic nerve trauma, which is one of a serious complication of craniocerebral trauma. lts prognosis poor and usually bring permanent vision damage. At present, optic nerve injury and regeneration is hot in neurobiology research. To build an ideal experimental animal model is extremely important in research and development in the treatment of optic nerve injury. ln this article, we review the methods of making rat models of traumatic optic neuropathy, clinical similarities, advantages and disadvantages of among these models, to provide reference for more experimental study.
出处
《国际眼科杂志》
CAS
2014年第12期2182-2184,共3页
International Eye Science
