慢性乙型肝炎病毒感染与代谢综合征的相关性分析

Association between Chronic Hepatitis B and Metabolic Syndrome

目的通过分析慢性乙型肝炎病毒(HBV)感染与代谢综合征(MS)之间的相关性,探讨慢性HBV感染是否为心血管疾病发生潜在的危险因素之一。方法采用横断面的分析方法 ,纳入2013年1月1日至2014年3月31日在新疆克拉玛依市中心医院参加体检的成年人,自制表格记录参与者一般资料及相关血清学指标,将确诊为慢性HBV感染患者分为男性组和女性组,通过Logistic回归分别探讨慢性HBV感染与MS及其组成部分的相关性。结果共4 437例参与者入组,其中确诊为慢性HBV感染患者为324例(7.3%),MS患者为115例(2.6%);在男性组,慢性HBV感染与高甘油三酯血症及MS呈负相关关系(P<0.05);在女性组,慢性HBV感染与高甘油三酯血症呈负相关关系(P<0.05),但与代谢综合征无显著相关性(P>0.05)。结论慢性HBV感染与男性高甘油三酯血症、MS及女性高甘油三酯血症呈明显负相关关系。

Objective The study was designed to discuss whether hepatitis B virus （HBV） infection was a risk factor for cardiovascular disease through analyzing the relationship between chronic HBV infection and metabolic syndrome. Methods A cross-sectional study was performed; adults who underwent a routine health check-up in our hospital from 2013-01-01 to 2014-03-31 were enrolled in the study. General information and relavent serological markers of the patients were collected. Patients confirmed with chronic HBV infection were divided into male and female groups. Association between HBV infection and metabolic syndrome were analyzed by Logistic Regression. Results Overall, 4 437 participants were enrolled,in which 324 （7.3%） were diagnosed aschronic HBV infection and 115 （2.6%） had metabolic syndrome. In the male group, HBV infection was significantly negatively associated with hypertriglyceridemia and metabolic syndrome（P〈0.05）. In the female group, HBV infection was also significantly negatively associated with hypertriglyceridemia（P〈0.05）, but not with metabolic syndrome （P〉0.05）. Conclusion HBV infection was significantly negatively associated with hypertriglyceridemia and metabolic syndrome in male and hypertriglyceridemia in female.