2008～2013年韶关市手足口病病原学分析

Etiological analysis on hand,foot and mouth disease in Shaoguang from 2008 to 2013

目的分析2008~2013年韶关市手足口病病原学流行特征,探讨病原变化对疫情的影响。方法采集全市手足口病聚集性疫情、重症及死亡病例咽拭子标本,采用RT-PCR的方法进行病毒核酸检测。结果病例标本总检出率为39.06%,EV71阳性率为30.91%,CA16阳性率为39.64%,其他肠道病毒阳性率为29.45%,EV71、CA16和其他肠道病毒存在混合感染及在不同年份所占比例存在差异。结论韶关市的手足口病病原复杂,EV71、CA16交替流行,对疫情的发生、发展和演变带来不确定性。

Objective To analyze the etiological characteristics of hand, foot and mouth disease （HFMD） from 2008 to 2013 so as to understand the etiological influence to epidemics. Methods Nasopharyngeal swabs of the cases from HFMD outbreak, severe and death were collected and assayed by RT-PCR. Results The general positive rate was 39.06%. The positive rates of EV71, CAI6 and other intestinal viruses were 30.91%, 39.64% and 29.45%, respectively. The proportion of EVT1,CA16 and other intestinal viruses was statistically significant in different years and there were polyinfection. Conclusion The pathogen of HFMD in Shaoguang was complex; EV71 and CA16 were the dominant pathogens. The alternating prevalence of EV71 and CA16 was one of the factors hindering the decreaseof the epidemic intensity of HFMD.