艾灸对力竭运动心肌细胞保护的研究进展

Progress of Researches on Protective Effect of Moxibustion on Myocardial Cells during Exhaustive Exercise

艾灸对消除运动疲劳,预防和保护心肌损伤的作用机制是当今运动医学界十分关注的研究方向。笔者查阅了近10年来艾灸防治运动性心肌损伤的相关文献后对其作用机制进行综述,发现艾灸主要从调节心肌细胞内分泌功能,清除自由基,抗氧化损伤,影响心肌细胞血液流变性几个方面发挥对力竭运动心肌细胞的保护作用,在此基础上,从分子水平提出艾灸对力竭运动心肌细胞保护的可能新机制——端粒酶调控机制。

Moxibustion is a side-effect-free external therapy for relieving different clinical disorders. Its effects in elimi- nating sports fatigue, preventing myocardial injury in people undergoing exhausted exercise and its underlying mechanisms have been induced great concern by the sports medicine community. In the present paper, the authors make a review on the develop- ment of researches on the underlying mechanism of moxibustion in the prevention and treatment of sports myocardial injury in re- cent 10 years from 1） regulating myocardial endocrine function, 2） scavenging free radicals, 3） resisting oxidative damage, and 4） modulating blood rheology. On the basis of results mentioned above, the authors raise a new potential mechanism underlying protective effect of moxibustion on myocardial cells during exhaustive exercise from the cellular molecular level, i.e., mitochon- drial telomerase-mediated anti-aging. This mitochondrial telomerase-mediated anti-aging may be a new target of moxibustion in- tervention for protecting cardiomyocytes from injury under exhaustive exercise condition.