鼻型结外NK/T细胞淋巴瘤中EB病毒感染与survivin的关系

EB virus infection and its relationship with survivin in extranodal nasal type NK/T cell lymphoma

目的讨论EB病毒感染与survivin在鼻型结外NK/T细胞淋巴瘤中的相关性。方法 1用原位杂交方法检测57例鼻型结外NK/T细胞淋巴瘤组织中EB病毒的表达;2用免疫组化法En Vision二步法检测57例鼻型结外NK/T细胞淋巴瘤中LMP1和survivin的表达。结果 157例鼻型结外NK/T细胞淋巴瘤中EB病毒、LMP1和survivin阳性率为80.7%(46/57)、56.1%(32/57)和75.4%(43/57);2LMP1的表达与survivin的表达有相关性(P<0.05),而EB病毒与survivin表达无显著相关性(P>0.05)。结论鼻型结外NK/T细胞淋巴瘤EB病毒感染与survivin无显著相关性。

Objective To investigate the correlation between EB virus infection and survivin in extranodal NK/T cell lymphoma, nasal type. Methods In situ hybridization was employed to detect the expression of EB Virus in 57 cases of extranodal NK/T cell lymphoma, nasal type; Immunohistochemical EnVision method was used to detect the expression of LMP1 and survivin in 57 cases of extranodal NK/T cell lymphoma, nasal type. Results The positive rate of EB virus, LMP1 and survivin were 80. 70% , 56. 14% and 75.44% , respectively; Thirty-two LMPl-positive samples were detected, forty-three survivin-positive cases were detected in all 57 cases of extranodal NK/T cell lymphoma, nasal type. There existed significant difference between the expression of LMP1 and survivin （ P 〈 0. 05 ） , but there was no close relation between EB virus infection and the expression of survivin （ P 〉 0. 05 ）. Conclusion There is no close association between EB virus infection and survivin in extranodal NK/T cell lymphoma, nasal type.