中药抗动脉粥样硬化机制研究进展

Advances in anti-atherosclerosis mechanisms of traditional Chinese medicine

动脉粥样硬化的病因及发病机制极为复杂,目前关于动脉粥样硬化的病因较为一致的看法是因脂质代谢紊乱、炎症细胞浸润、氧化应激、血管内皮细胞损伤、平滑肌细胞激活等多种机制相互作用的结果,最终导致斑块的破裂,血栓形成,造成严重心脑血管疾病。中药对心血管系统疾病具有良好的临床防治效果,部分中药复方和单体抗动脉粥样硬化的多靶点协同作用机制已经得到了初步的阐明。本文从调节脂质代谢、抗炎、抗氧化、保护血管内皮细胞、抑制平滑肌细胞的增殖和迁移、改善凝血纤溶系统及稳定斑块等方面对相关中药抗动脉粥样硬化的作用机制进行综述。

Cardiovascular and cerebrovascular diseases, including coronary heart disease, periph-eral vascular disease and atherosclerosis, are the first cause of death worldwide. The pathogenesis of atherosclerosis is a complex process that involves a number of cellular processes and molecular mecha-nisms, such as disorder of lipid metabolism, inflammatory cell infiltration, oxidative stress, vascular en-dothelial cells injury and activation of smooth muscle cells. Their interaction eventually leads to plaque rupture and thrombus formation, causing serious cardiovascular and cerebrovascular events. Chinese medicine has displayed rich anti-AS activities and clinical applications. This review summarizes the anti-atherosclerosis effects and possible mechanisms of Chinese medicine in regulating lipid metabolism, anti-inflammation and antioxidation, protecting endothelial cells, inhibiting the proliferation and migration of smooth muscle cells, improving coagulation and fibrinolysis systems and stabilizing the plaque.