新疆维吾尔自治区墨玉县维吾尔族成人代谢综合征与慢性肾脏病的相关性研究

Association of metabolic syndrome and chronic kidney disease among Uygur adults in Moyu country in Xinjiang Uygur Autonomous Region

目的：分析代谢综合征（MetS）及其组分[超重和（或）肥胖、高血糖、高血压、血脂紊乱]对新疆维吾尔自治区墨玉县农村维吾尔族成人慢性肾脏病（CKD）的影响。方法选取“新疆维吾尔自治区墨玉县农村维吾尔族成年人慢性肾脏病（CKD）及其危险因素流行病学调查”资料库中的1552名资料完整的研究对象，使用SPSS 15.0软件进行MetS与CKD的相关性分析。结果 MetS的患病率14.18%（220/1552），年龄性别标准化后为14.45%（95%CI 14.30%～14.60%）。MetS人群（220例）的白蛋白尿（7.27%比3.83%，χ2=5.42，P=0.02），肾功能（eGFR）下降（9.55%比3.45%，χ2=16.96，P=0.00）及CKD患病率（13.64%比6.76%，χ2=12.52，P=0.00）均高于非MetS组（1332例）。MetS组分个数和CKD患病率正相关（χ2=9.64，P=0.00），有4个MetS组分的患者合并CKD的危险性最高（OR=7.15，95%CI 2.29～22.26，P=0.00）。结论新疆维吾尔自治区墨玉县农村维吾尔族成人MetS与CKD的患病率相关，应针对性的早期干预高血压、脂代谢紊乱，调节血糖，做到早期防控CKD。

Objective To examine the effects of different compositions of metabolic syndrome [Overweight and （or） obesity, hyperglycemia, hypertension, dyslipidemia] on chronic kidney disease. Methods A total of 1552 health data were collected from the survey of chronic kidney diseases among Uygur adults in Moyu country in Xinjiang Uygur Autonomous Region and the relationship between metabolic syndrome and chronic kidney disease was analyzed by using SPSS 15.0 software package. Results Before and after adjusting of age and gender, the prevalence of metabolic syndrome was 14.18% and 14.45% （95% CI 14.30%-14.60%）. The prevalence of albuminuria （7.27% vs 3.83%, χ2=5.42, P=0.02）, reduced estimated glomerular filtration rate （9.55% vs 3.45%, χ2=16.96, P=0.00） and chronic kidney disease（13.64% vs 6.76%, χ2=12.52, P =0.00） increased in residents diagnosed as metabolic syndrome than those without metabolic syndrome. The prevalence of chronic kidney disease increased with the increasing number of metabolic syndrome elements. Conclusions The prevalence of chronic kidney disease is associated with the accumulation of metabolic syndrome compositions. Early intervention on metabolic risk factors may reduce the risk of chronic kidney disease.