绝经后妇女血清OPN水平与骨密度及骨转换水平的相关性研究

Relation between serum osteopontin level and bonemineral density and bone turnover markers in postmenopausal women

目的研究绝经后女性血清骨桥蛋白(OPN)水平与骨密度(BMD)、骨标志物的关系,探索OPN在绝经后骨质疏松症(PMOP)中的临床应用价值。方法对125名绝经后女性进行研究,双能X线骨密度仪测量腰1-4及左股骨颈BMD,测定血中I型原胶原N-端前肽(PINP)、β-胶原降解产物(β-CTX)、25羟维生素D、甲状旁腺素、OPN、骨钙素(OC)、钙(Ca)和磷(P)。结果 1骨质疏松组血清OPN水平明显高于骨量减少和正常组(F=0.118,P=0.000);2血清OPN水平与BMD(腰1-4,左股骨颈)、血Ca显著负相关,与年龄、β-CTX、OC显著正相关(P均<0.05);3多元线性回归分析结果表明,左股骨颈骨密度(B,-11.971;SE,2.383;标准系数,-0.402;P=0.000)、血钙(B,-6.696;SE,2.383;标准系数,-0.225;P=0.006)是OPN水平独立预测因子。结论高血清OPN水平与低BMD、高β-CTX水平及钙缺乏相关,该结果丰富了现有的临床证据,为防治PMOP提供了新的思路。

Objective To study the relationship between osteopontin （ OPN） and bone mineral density （ BMD） and bone turnover markers in postmenopausal women, and to explore the clinical value of OPN in postmenopausal osteoporosis.Methods One hundred and twenty-five postmenopausal women were selected in the study.BMD of the lumbar spine 1-4 and the left femoral neck was measured using dual-energy X-ray absorptiometry.Levels of serum procollagen type I N-terminal propeptide （ PINP ） , β-crosslaps （β-CTX）, 25-hydroxyvitamin D （25OHD）, parathyroid hormone （PTH）, OPN, osteocalcin （OC）, calcium （Ca）, and phosphorus（P） were measured.Results ①Osteopontin level in osteoporosis group was significantly higher than that in osteopenic and normal group （F=0.118, P=0.000）.②BMD and Ca were negatively correlated, while age, β-CTX, and OC were positively with OPN （ all P 〈0.05 ） .③Multiple regression analysis showed that BMD of left femoral neck and Ca were independent predictors of the serum OPN level.Conclusion High level of OPN is associated with low BMD, increased level ofβ-CTX, and the lack of Ca, which enriches the existing clinical evidence and provide a new idea for controlling postmenopausal osteoporosis.