摘要
本研究旨在探讨F-18 FDG PET/CT在噬血细胞综合征(HPS)的诊断和预后判断中的作用。回顾性分析了11例行F-18 FDG PET/CT检查的HPS患者,评估了F-18 FDG PET/CT对HPS相关的恶性肿瘤的诊断价值,计算了骨髓和脾脏的最大标准摄取值(SUVmax),对骨髓和脾脏的SUVmax与HPS的多个实验室参数以及临床转归的关系进行了分析。结果表明:11患者中4例伴恶性肿瘤;通过F-18 FDG PET/CT检测判断HLH患者是否伴有恶性肿瘤的敏感性、特异性和准确性分别为100.0%、66.7%和75.0%;骨髓和脾脏的SUVmax与实验室参数无显著的相关性;预测患者预后的脾脏SUVmax值和骨髓SUVmax值的最佳截断点分别为3.10和3.47;单因素分析提示,骨髓和脾脏中F-18 FDG高摄取患者的存活时间较短。结论:F-18 FDG PET/CT在继发性HPS的病因诊断和预后判断中具有重要作用。
The aim of this study was to investigate the role of F-18 fluoro-2-deoxyglucose positron emission tomography/computed tomography（ F-18 FDG PET /CT）in diagnosis and prognostic evaluation of secondary hemophagocytic syndrome（ HPS）.A total of 11 secondary HPS patients examined with 18F-FDG-PET /CT were retro-spectively analyzed.The diagnostic value of F-18 FDG PET /CT for malignancy detection was assessed.The values of maximum standardized uptake value（ SUVmax） in spleen（ SUVsp） and in bone marrow（ SUVbm） were measured to analyze their relationship with various laboratorial parameters and clinical outcome of secondary HPS patients.The results showed that4 out of the 11 patients had malignanciesthe sensitivityspecificity and diagnostic accuracy of F-18 FDG PET /CT for malignancy detection were 100%66.7% and 75% respectivelythe SUVof spleen and bone marrow showed no significant correlation with laboratorial parametersa maximum SUVof 3.10 and a maximum SUVof 3.47 were the optimal cutoffs for predicting patients＇ outcomethe increased uptake of F-18 FDG in the BM and spleen were significantly associated with shorter survival time according to univariate analysis.It is concluded that 18F-FDG PET /CT may especially play an important role in diagnosis and predicting outcome of secondary HPS for the small sample size.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2014年第6期1698-1701,共4页
Journal of Experimental Hematology
基金
国家自然科学基金(81270573)
安徽省级高校自然科学基金(KJ2012Z188)
