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7号染色体异常在髓系恶性肿瘤中的意义 被引量：2

Significance of Chromosome 7 Abnormalities in Myeloid Malignancies——Review
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摘要 7号染色体异常在髓系恶性肿瘤中是常见的遗传学现象,伴有7号染色体异常的髓系恶性肿瘤常与粒细胞运动缺陷、易于感染、疾病进展迅速及对治疗反应较差相联系,因而推测7号染色体上含有重要的抑癌基因。近年来通过荧光原位杂交、单核苷酸多态性微阵列等分子生物学技术,研究者确定了一些7号染色体的共同缺失片段(例如7q22等),并对缺失片段上的基因(EZH2、MLL5、DOCK4、SAMD9L/SAMD9)在髓系恶性肿瘤发生发展过程中的生物学作用进行了深入研究。本综述就髓系恶性肿瘤中7号染色体异常的定位分析方法、缺失的基因及功能、治疗及预后等方面进行综述。 Chromosome 7 abnormalities are the most common cytogenetic alterations found in myeloid malignancies.Myeloid malignancies exhibiting monosomy 7 /del（ 7q）have been confirmed to associate with high susceptibility to infectionspoor response to chemotherapyand short survival timeso speculating that chromosome 7 has important tumor suppressor genes.Commonly deleted segments（ such as 7q22 ）of chromosome 7 have been identified by FISH and other technologies.Genes（ EZH2MLL5DOCK4SAMD9 L /SAMD9） located in commonly deleted segments of7 q have been cloned and characterized along with the advance of molecular biology.This review summaries the current advancement about myeloid malignancies associated with monosomy7 /del（7q）.
作者 史文慧 李晓 常春康
机构地区 上海交通大学附属第六人民医院血液科
出处 《中国实验血液学杂志》 CAS CSCD 北大核心 2014年第6期1739-1743,共5页 Journal of Experimental Hematology
关键词 7号染色体 基因 髓系恶性肿瘤 chromosome 7 gene myeloidmalignancy
分类号 R733.7 [医药卫生—肿瘤] Q343.244 [生物学—遗传学]
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参考文献40

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中国实验血液学杂志
2014年 第6期

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