治疗相关性骨髓增生异常综合征/急性髓系白血病研究进展

Recent Advances of Studies on the Therapy-Related Myelodysplastic Syndromes/Acute Myeloid Leukemia——Review

随着现代肿瘤治疗方案的不断改进,长期存活患者的比例不断提高,作为远期并发症的放、化疗所致的治疗相关性髓系肿瘤也越来越受到重视。根据2008年WHO诊断标准,治疗相关髓系肿瘤包括既往因肿瘤性疾病或非肿瘤性疾病行细胞毒药物化疗或放疗后而导致的急性髓系白血病AML(t-AML)、骨髓增生异常综合征(t-MDS)和t-MDS/骨髓增殖性肿瘤(t-MDS/MPD)。本文就t-MDS/AML的发病机制、与原发肿瘤的关系、治疗及预后进行如下综述。

Therapy-related myelodysplasia syndromes /acute myeloid leukemia（ t-MDS /AML） is a clinical syndrome occurring as a late complication after chemotherapy and（ or）radiotherapyattracting much more attention owing to the improved treatment agents and longer survival of many treated patients.According to the WHO classification of 2008t-MDS /AML is a serious complication of chemotherapy or radiotherapy given to a malignant or nonmalignant condition consisting of t-AMLt-MDS and t-MDS /myeloproliferative diseases（ t-MDS /MPD）.This review mainly focuses on the pathogenesisrelationship with primary tumourtreatment and prognosis of t-MDS /AML.