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慢性阻塞性肺疾病中肺血管病变研究进展 被引量：4

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摘要 慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）是以不可逆气流受限为特征的疾病,虽然其病变主要累及气道,但肺血管的损伤也是该疾病重要的病理生理改变.肺血管损害普遍存在于COPD患者中,轻度COPD患者即有显著的肺血管结构和功能的异常[1].肺血管功能受损可影响气体交换,并可导致肺动脉高压,而肺动脉高压的发生与COPD患者生存率的降低密切相关[2].目前COPD中肺血管损伤的具体机制仍未完全明了,本文就近年来肺血管损伤的研究进展作一综述.
作者 李进华 陈燕 蔡珊 彭红 陈平
机构地区 中南大学湘雅二医院呼吸内科
出处 《中国医师杂志》 CAS 2014年第11期1468-1472,共5页 Journal of Chinese Physician
关键词 肺疾病 慢性阻塞性 肺疾病 血管疾病 综述
分类号 R563.9 [医药卫生—呼吸系统]
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参考文献35

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同被引文献45

  • 1无.肺动脉高压筛查诊断与治疗专家共识[J].中华心血管病杂志,2007,35(11):979-987. 被引量：271
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  • 3Borg BM, Reid DW, Waiters EH, et ai. Bronchodilator reversibili- ty testing:laboratory practices in Australia and New Zealand [ J ]. Med J Aust,2004,180(12) :610-613.
  • 4Lehmann S, Bakke PS, Eide GE, et al. Bronchodi|ator reversibility testing in an adult general population;the importance of smoking and anthropometrical variables on the response to a beta2-agonist [ J]. Pulm Pharmacol Ther,2006,19(4) :272-280.
  • 5陕振秀,张志红.COPD住院患者行为方式与家庭支持的调查[J].中国医师杂志,2014,16(z1):239-240.
  • 6Galib N, Humbert M, Vachiery JL, et al. 2015 ESC/ERS Guide- lines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology ( ESC ) and theEuropean Respiratory Society (ERS) : Endorsed by : Associa- tion for European Paediatric and Congenital Cardiology ( AEPC), International Society for Heart and Lung Transplantation (ISHLT) [J]. Eur Respir J, 2015,46 (4) : 903-975.
  • 7Vachi6ry JL. Prostacyclins in pulmonary arterial hypertension: the need for earlier therapy [ J ]. Adv Ther, 2011 Apr; 28 (4) : 251- 269.
  • 8Miyata M, Ueno Y, Sekine H, et al. Protective effect of beraprost sodium, a stable prostacyclin analogue, in development of mono- crotaline-induced pulmonary hypertension [ J ]. J Cardiovasc Phar- macol, 1996, 27 ( 1 ): 20-26.
  • 9Ono F, Nagaya N, Okumura H, et al. Effect of orally active pros- taeyelin analogue on survival in patients with chronic thromboem- bolic pulmonary hypertension without major vessel obstruction [ J].Chest, 2003, 123(5): 1583-1588.
  • 10ATS Committee on Proficiency Standards for Clihieal Pulmonary Funotion Laboratories. ATs statement: guidelines for the six-minute walk test [ J ]. Am J Respir Crit 117.

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中国医师杂志
2014年 第11期

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