胰岛素样生长因子1受体在眼科疾病中的研究进展

Research progress of IGF-1R in ophthalmology

胰岛素样生长因子1受体（IGF-1R）是酪氨酸蛋白激酶家族的成员,通过介导IGF-1的活性促进细胞增生、转移并抑制细胞凋亡,与眼科多种疾病的发生和发展密切相关.IGF-1R在脉络膜黑色素瘤中的表达水平与肿瘤的多种生物学特性,如侵袭和转移等密切相关,同时IGF-1R可能与促甲状腺激素受体（TSHR）共同作用并通过多种信号通路参与甲状腺相关眼病的发生和发展,通过胰岛素受体底物1（IRS-1）作用于血管内皮生长因子（VEGF）,从而促进视网膜新生血管性疾病的发生和发展,在眼科其他疾病,如屈光不正、白内障等中也发现IGF-1R相关生物学效应,提示IGF-1R作为分子靶位点将成为眼科疾病基因治疗的一个新课题.就IGF-1R在眼科疾病中的研究进展进行综述.

Insulin-like growth factor 1 receptor （IGF-1 R）,a member of the family of tyrosine protein kinase,mediates the activity of the IGF-1.IGF-1R can promote the proliferation and migration of cells and inhibit the apoptosis of cells.IGF-1R shows a high level expression and presents a close relationship with a variety of biological characteristics such as invasion and metastasis of choroid melanoma,and it influences the pathogenesis and progress of thyroid related ophthalmopathy,working together with thyroid stimulating hormone receptor （TSHR） through different signaling pathways.Also IGF-1 R,targeting vascular endothelial growth factor （VEGF）,may promote the pathogenesis and development of new retinal vascular diseases through the insulin receptor substrate 1 （IRS-1）.Other IGF-1R related biological effects were found in eye diseases,such as refractive error and cataract,ect.,hinting us that as a molecular targete,IGF-1R will become a new topic of gene therapy for eye diseases.