甲型流感病毒PA蛋白新成员的研究进展

Research Progress in Novel PA Protein Members of Influenza A Viruses

流感严重地威胁着人们的生活和健康,研究流感病毒的蛋白组成将有助于流感病毒疫苗及检测试剂等的研发。流感病毒含有结构和非结构蛋白。最初人们认为甲型流感病毒的8个基因节段只能编码8个病毒蛋白,以后发现M基因和NS基因可以分别编码M2离子通道蛋白和非结构蛋白NS2。自2012年以来人们从甲型流感病毒中鉴定出了数种新的病毒蛋白,本文将主要介绍于2012年和2013年分别发现的甲型流感病毒PA蛋白新成员PA-X、PA-N155和PA-N182。

Influenza poses a great threat to life and health in populations worldwide.Studies regarding the protein components of influenza viruses will facilitate the research and development of vaccines and diagnostic reagents.The influenza virus contains both structural and non-structural proteins.From the outset,it has been accepted that an influenza A virus possesses eight gene segments that encode eight corresponding viral proteins,respectively.Research has demonstrated that the M gene encodes the M2 ion channel protein and the NS gene encodes the non-structural protein,NS2.In recent years,several novel viral proteins have been identified from influenza A viruses.This article will briefly describe the state of current research into PA-related proteins of influenza A viruses.