施马伦贝格病毒研究进展

A Review of Research on Schmallenberg Virus

施马伦贝格病毒(Schmallenberg virus,SBV)是2011年新发现的布尼亚病毒科(Bunyaviridae)的病毒,主要侵害反刍动物的中枢神经系统,导致牛或羊产奶减少以及胎儿畸形或死胎等。截至2014年6月,关于该病发表的科研文献已经达到200多篇。我国虽然已有20多篇文献报道,但大多数文献只对该病进行了简单介绍,没有全面展示该病毒的研究进展。作为新发病,国家外来动物疫病研究中心一直将该病作为研究重点。本文就SBV的病原学、流行病学、诊断技术以及疫苗研发等进行详细介绍,以期为我国SBV的防控及研究提供参考。

Schmallenberg virus（SBV）,a novel orthobunyavirus,was first isolated in 2011.SBV preferentially infects the central nervous system of cattle and sheep and causes fever,diarrhea,a drop in milk yields,congenital malformations and stillbirths.Until June 2014,more than 200 scientific publications regarding SBV have been published.Although more than 20 articles on SVB were published in China,most of these articles provided only a brief introduction of the disease without fully discussing the associated disease characteristics.As a new disease,it has been made a focus of the National Research Center for Exotic Animal Diseases at the China Animal Health and Epidemiology Center.In this review,in order to provide a reference for research into SBV in China,we have reviewed the state of current research progress on the etiology,diagnosis and epidemiology of SBV,and vaccine development.