促炎细胞因子在交感／儿茶酚胺介导心脏重塑中的作用

Roles of proinflammatory cytokines in cardiac remodeling induced by sympathetic nervous system / catecholamine

高血压和心力衰竭等心血管疾病是低度非感染性炎症反应性疾病，其病理过程是在非外源性感染因素造成的组织损伤作用下，外周血白细胞（包括淋巴细胞、单核-巨噬细胞、中性粒细胞等）向靶器官浸润，自身或促进靶器官合成和分泌细胞因子，后者通过自分泌或旁分泌的途径发挥生物学功能。

Sympathetic nervous system is excessively activated under strong stress, which leads to a significant rise of plasma catecholamine concentration, then activates the β-adrenoceptors （β-ARs） in the heart and mediates the development of cardiac remodeling and heart failure. Meanwhile, chronic β-ARs activation has been proved to be involved in cardiac sterile inflammation by mediating the synthesis and secretion of cytokines, which subsequently mediates cardiac fibrosis and dysfunction. This review summarizes a number of important proinflammatory cytokines involved in the process of cardiac pathological remodeling under chronic adrenergic stimulation and the application of neutralizing antibodies on specifically targeting cytokines in the treatment of cardiovascular diseases.