糖尿病视网膜病的免疫机制研究进展被引量：4

A close view into the immunological mechanisms of diabetic retinopathy

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摘要糖尿病视网膜病变(DR)作为糖尿病患者晚期出现严重视力障碍甚至致盲的主要病因之一,也是糖尿病晚期出现全身微血管病变的重要局部表现。它直接导致糖尿病患者晚期生活质量出现严重下降。在现有的研究结果显示,免疫炎症因子作用与DR的产生与进展息息相关,其中以ICAM-1、抗内皮细胞抗体、TNF-α、VEGF、补体、HLA等的作用尤为突出,并一直作为研究热门方向被广泛关注。以下将对相关免疫炎症因子在DR中的作用机制进行综述。 Diabetic reaopathy （ DR）, one of the leading causes that result in serious visual impairment or blind- ness, was part of systemic microvascular complications of diabetes. DR seriously impairs the quality of life in diabetic pa- tients. Becent researches suggested that the development of DR may be associated with inflammatory immune factors such as ICAM-1, endothelial cell antibodies, TNF-R, VEGF, complements o and HLA. The immunological mechanisms of DR have become a heated area of research. The aim of the present review is to provide an overview of immunological mechanisms of DR.

作者李桢郎平吴昌凡方严

机构地区皖南医学院附属弋矶山医院眼科

出处《临床眼科杂志》 2014年第6期567-570,共4页 Journal of Clinical Ophthalmology

关键词糖尿病视网膜病变免疫机制炎症因子 Diabetic vetinopathy Immunological mechanisms Ivflammatory factor

分类号 R587.2 [医药卫生—内分泌]

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