Hippo信号通路在雌性生殖系统中的研究进展

Research Progress on Hippo Signaling Pathway in Female Reproductive System

Hippo信号通路是一条存在于果蝇属和哺乳动物体内的保守且新兴的信号通路,具有复杂多变的特点。该通路由多种抑癌基因和一种原癌基因组成,与其他信号通路存在诸多交联对话。Hippo信号通路具有调控器官大小、参与调节细胞周期和凋亡及维持内环境稳定等生物学效应。近年来已有研究表明,Hippo信号通路参与雌性生殖系统发育的调控,因此,其在生殖系统发育及疾病治疗中的作用逐渐引起人们的广泛关注。该文综合论述了Hippo信号通路的生理特性及功能,着重阐述其在雌性生殖系统主要生殖器官(如卵巢、乳腺及卵泡等)中的调控机制。

The Hippo signaling pathway is a recently discovered signal transduction pathway in Drosophila and mammals, which is a broadly conserved and novel pathway comprised multiple of tumor suppressor genes and an oncogene. The Hippo pathway has complex characteristics and cross-linking dialogue with other signaling pathways. It has been accepted to play an important role in the regulation of organ size, cell cycle, apoptosis and maintenance of their homeostasis. Recent findings suggested that the Hippo pathway regulate female reproductive system development. Therefore, more and more researchers pay attention to Hippo pathway research in female re- productive system development and its application in disease treatment. In this study, we discussed the physiologi- cal characters and functions of Hippo pathway, and emphasized the regulation in female reproductive system, such as ovary, mammary gland, follicle, etc.