TRPC3、TRPC6分子与高血压的研究进展

Advances in Research of Relations Between TRPC3,TRPC6 and Hypertension

近年来,研究发现TRPC3、TRPC6在心血管疾病中发挥重要作用。高血压作为心血管疾病中发病率和死亡率最高的疾病之一,其发生机制与TRPC3、TRPC6表达紧密相关。细胞内钙稳态失衡是形成高血压的主要因素,Ca2+浓度变化依赖于Ca2+跨膜转运、细胞内钙库释放以及再摄取Ca2+等过程的动态平衡,而TRPC3、TRPC6分子作为细胞膜上的非选择性阳离子通道恰是参与这些过程的重要分子。该文针对TRPC3、TRPC6分子的表达在高血压形成中的作用以及二者对心肌细胞和平滑肌细胞的影响进行综述,同时对西地那非等药物治疗高血压机制进行分析,旨在为高血压疾病的预防和治疗提供新途径。

Recently, studies found that TRPC3 and TRPC6 played an important role in cardiovascular disease. Hypertension, as a cardiovascular disease causing the highest morbidity and mortality, has close relationship with the expressions of TRPC3 and TRPC6. Unbalanced calcium homeostasis is the major factor of pathogenesis of hypertension. Changes of intracellular calcium concentration depend on calcium transmembrane transportation, intracellular calcium store releasing and other processes. TRPC3 and TRPC6, as non-selective cation channels on the cell membranes, are involved in the processes. This review tries to analyze the function of TRPC3 and TRPC6 in the development of hypertension through the myocardial cells and smooth muscle cells, and the effects of drugs like Sildenafil to provide a new way for the prevention and treatment of hypertension.