趋化因子CXCL1在肿瘤中的作用

The Role of Chemokine CXCL1 in Tumor Progress

趋化因子及其受体在许多生物学过程(如炎症发生、血管生成等)中起重要的作用。趋化因子CXCL1是单亚基趋药性细胞因子,该蛋白主要通过特异性结合G蛋白耦联受体CXCR2,在多种肿瘤的生长、增殖、转移和侵袭以及血管新生中起重要调控作用。该文重点阐述了趋化因子CXC亚家族成员CXCL1在肿瘤中的功能,并对其上游调控因子进行分析,深入探讨了CXCL1与肿瘤的相互关系。

Chemokines and their receptors play an important role in many biological processes such as inflammation and angiogenesis. Chemokine CXCL1 is a monomeric protein of chemotaxis cytokines. It usually binds to G protein coupled receptor CXCR2 specifically, and has effects on tumor growth, proliferation, metasta- sis, invasion and angiogenesis in various cancers. This paper mainly focuses on the role of a subfamily member of chemokine CXCs, CXCL1 in tumors, and of upstream regulatory factors on its expression, in order to explore the relationship between CXCL1 and tumor progress.