miRNA在HPV相关肿瘤发生中的作用

Roles of miRNAs in HPV-related cancers

高危型人乳头瘤病毒（HR—HPV）与宫颈癌、头颈部肿瘤等发生发展密切相关。微小RNA（miRNA）为20～25nt的小分子非编码RNA，参与肿瘤的增殖、凋亡、侵袭和转移等多种生物学过程。HR—HPV基因组可整合人宿主细胞基因组内，并表达病毒癌基因E6、E7以及E5等，从而影响下游的p53、pRb等基因以及miRNA的表达，导致宿主细胞发生癌变（中华检验医学杂志，2014，37：977-981）

High-risk human papillomavirus infection is the major cause of tumors such as cervical cancer and head and neck cancer. MicroRNAs （miRNAs） are 20-25nt small non-coding RNAs, which are involved in the proliferation, apoptosis, invasion and migration of tumors. HR-HPVs, which integrate into the host genome, encode three oncogenes： E6, E7 and E5 and enhance carcinogenesis by regulating downstream miRNAs and genes e.g. p53 and pRb. （Chin J Lab Med,2014,37：977-981）