滋肾柔肝汤治疗抗精神病药物所致高催乳素血症患者不良反应临床研究

Clinical Study of Zishen Rougan Decoction on Adverse Reactions of Patients with Hyperprolaetinemia Caused by Antipsyehotics

目的:探讨滋肾柔肝汤治疗抗精神病药物所致高催乳素血症患者对其社会功能的影响。方法:120例患者随机分成滋肾柔肝汤组(治疗组)和安慰剂组(对照组),滋肾柔肝汤和安慰剂剂量均为150 m L日2次,分别于治疗前及治疗后4周、8周及12周末进行中医证候量表及个人与社会功能量表(PSP)评定。结果:完成有效病例118例,滋肾柔肝汤组完成56例,安慰剂组完成62例。与治疗前比较,治疗组在治疗后中医证候量表及PSP评分均有高度统计学意义(P<0.01),而对照组治疗前后比较未见统计学差异;中医证候量表评分及PSP评分两组在治疗前比较无显著性差异,治疗12周后两组间比较差异存在统计学意义(P<0.05,P<0.01)。结论:滋肾柔肝汤可显著改善抗精神病药物所致高催乳素血症患者的不良反应。

Objective：To discuss the effect of Zishen Rougan decoction on social function of patients with hyperprolaetinemia by antipsyehotics. Methods：One hundred and twenty patients were divided into randomly two groups,and received Zishen Rougan decoction（treatment group） or placebo（control group）. The doses of Zishen Rougan decoction and placebo were 150 mL bid daily. Respectively,before and after treatment 4 weeks,8 weeks and 12 weekends TCM Syndrome Scale and Personal and Social Functioning Scale（PSP） were evaluated. Results：One hundred and eighteen effective patients were completed,56 patients in treatment group and 62 patients in control group. As compared with the baseline,significant differences in TCM Syn- drome Scale total score and PSP score were shown in treatment group after treatment（P〈0.01）. Comparison between groups showed that significant differences presented in TCM Syndrome Scale total score at the end of the 8th and 12 th week and PSP score at the end of the 4th,8th and 12th week（P〈0.05,P〈0.01）. Conclusion：Zishen Rougan decoction can significantly improve patients adverse reactions of hyperprolactine- mia caused by antipsychotics.