TCT联合HPV检测诊断宫颈病变的临床价值分析

Analysis of the Clinical Value of TCT Combined with HPV Testing in the Diagnosis of Cervical Lesions

目的:探讨新柏氏液基细胞学技术(TCT)联合人乳头瘤病毒(human papilloma virus,HPV)检测诊断宫颈病变的临床价值。方法:选择哈尔滨医科大学附属第一医院妇科门诊收治的6752例患者,采集其宫颈脱落细胞进行TCT检测,登记患者的年龄及宫颈外观。分别随机选取TCT阳性和阴性结果的患者144例进行HPV检测及阴道镜下活检,分析和比较TCT单独及联合HPV检测诊断宫颈病变的敏感性和特异性。结果:宫颈柱状上皮细胞的外移程度及患者的年龄与宫颈TCT结果均无显著相关性。单独TCT检测诊断宫颈病变的灵敏度为87.04%,特异性为58.55%;单独HPV检测诊断宫颈病变的灵敏度为62.96%,特异性为81.62%;而联合测诊断宫颈病变的灵敏度为100%,特异度为48.29%。结论:TCT联合HPV检测可显著降低宫颈病变的漏诊率。

Objective： To study the clinical value of TCT combined with HPV testing in the diagnosis of cervical lesions. Methods：The desquamated cells of uterine tube of 6752 patients were collected in Harbin hospital and conducted the TCT test, while each patient＇s age and uterine tube appearance were registered. 144 cases were selected from the positive and negative results of TCT randomly and were examined by HPV and colposcopy biopsy, the sensitivity and specificity of TCT alone and combined with HPV detection in the diagnosis of cervical lesion were analyzed and compared. Results： No significant correlation was found between the moving of cells in columnar epithelium of the uterine tube and uterine tube TCT result. Moreover, no obvious correlation was found between the age and TCT result of uterine tube. The sensitivity and specificity of TCT test alone were 87.04% and 58.55% respectively, which were 62.96%and 81.62% of HPV test alone, 100% and 48.29% of TCT combined with HPV test in the diagnosis of cervical lesion. Conclusion： TCT combined with HPV detection could significantky lower the rate of missed diagnosis in the diagnosis of cervical lesions.