摘要
糖尿病是一种常见病、多发病,严重威胁着人类的健康。现已明确,糖尿病是冠心病发病的一个重要因素。心肌缺血/再灌注(ischemia/reperfusion,I/R)损伤是临床常见的病理过程,同时是冠心病发病及心肌血运重建治疗过程中的核心环节,如何减轻I/R损伤一直是国际研究热点之一。糖尿病与I/R损伤对心肌都有损害作用,相关研究证明糖尿病能够进一步恶化I/R损伤对心肌的损伤作用。研究表明,缺血预处理(ischemia preconditioning,IPC)可以延缓或减轻心肌I/R损伤,同时,麻醉药预处理(anesthetic induced preconditioning,APC)也具有IPC样的心肌保护作用。其中,七氟烷作为现阶段临床较常用的吸入麻醉药,同样对心肌I/R损伤具有保护作用。本文就七氟烷对糖尿病心肌I/R损伤的影响及其机制做一综述。
Diabetes Mellitus（DM） is a frequently-occurring disease. It＇s seriously threatening people＇s health. And it is one of the important factors to coronary heart disease. Myocardial ischemia / reperfusion（I/R） injury is a common pathological process, and how to reduce I/R injury has been one of the international hot points. DM and I/R injury both hurt heart function, and related research demonstrates that DM can enhance myocardial I/R injury. Studies show that ischemia preconditioning（IPC） can release myocardial I/R injury,and anesthetic induced-preconditioning（APC） has the same protective effect as IPC. Sevoflurane is one more common inhalational anesthetic, and has protective effect on myocardial I/R injury, too. This paper is about the influence and mechanism of sevoflurane to diabetes myocardial ischemia/reperfusion injury.
出处
《现代生物医学进展》
CAS
2015年第1期198-200,共3页
Progress in Modern Biomedicine
关键词
七氟烷
糖尿病
缺血/再灌注损伤
Sevoflurane
Diabetes mellitus
Ischemia/reperfusion injury
