生长分化因子-15在急性冠脉综合征中的临床研究

Clinical Studies of Growth Differentiation Factor-15 in Acute Coronary Syndrome

生长分化因子-15(growth differentiation factor-15,GDF-15)是转化生长因子超家族的成员之一。近年来有实验室及临床研究发现,生长分化因子-15在心肌缺血或缺血/再灌注损伤时可高表达,并减少心肌细胞坏死的数量,抑制缺血心肌细胞的凋亡。在心肌压力超负荷的情况下,生长分化因子-15高表达或给予外源性生长分化因子-15可抑制心肌肥厚及心脏扩大,保护心功能。而在临床研究中发现急性冠脉综合征的患者生长分化因子-15增高,与部分心血管的危险因素存在相关性,对患者的预后有提示作用。

Growth differentiation factor-15 （GDF-15）is a member of the transforming growth factor-[3 superfamily. Recent experimental research and clinical studies have found that GDF-15 is highly expressed in myocardial ischemia or ischemia/reperfusion injury, which can reduce myocardial necrosis and apoptosis. In the condition of pressure overload, GDF-15 over expression, or exogenous GDF-15, can inhibit myocardial hypertrophy and dilation, appearing to have a cardio-protective effect. Some clinical studies show that the circulating level of GDF-15 is significantly higher in patients with acute coronary syndrome, GDF-15 may provide predictive information for patients.