铁蛋白与CA125联合检测在良、恶性腹水鉴别诊断中的临床意义

Clinical significanceof tumor markers of tumor ferritin,CA125 combined detection in benign and malignant ascites' differential diagnosis

目的研究肿瘤标志物铁蛋白与CA125联合检测在良、恶性腹水鉴别诊断中的临床意义。方法选取2011年1月-2013年12月阳新县妇幼保健院收治的147例腹水患者,空腹抽取晨间静脉血后,采用免疫法和化学发光法测定铁蛋白、CA125水平,并对血清和腹水铁蛋白、CA125水平及诊断结果进行比较分析。结果恶性腹水组的血清、腹水铁蛋白水平和腹水/血清比值均显著高于良性腹水组;恶性腹水组血清、腹水CA125水平和腹水/血清比值均显著高于良性腹水组,差异均有统计学意义(均P<0.05)。联合检测方案的敏感性、准确性最佳,其中腹水敏感度为89.0%,准确度为91.3%;血清敏感度为75.7%,准确度为82.3%。结论铁蛋白与CA125联合检测对鉴别良、恶性腹水具有重要的诊断价值,值得临床推荐应用。

[ Objective ] To study the clinical significance analysis of tumor markers of tumor ferritin, CA125 com- bined detection in benign and malignant ascites, differential diagnosis. [Methods] From January 2010 to December 2013, the hospital treated a total of 147 cases of patients with ascites. Took the morning fasting venous blood used immunoassay and chemiluminescence. To test ferritin and CA125 levels, compared with serum and ascites＇ferritin and CA125 levels, and result of serum, ascites ferritinand CA125 diagnosis. [Results] The malignant ascites group＇s ascites and serum ferritin level, ascites/serum ratio were significantly higher than benign ascites group; the malignant ascites group＇s ascites and serum CA125 level, ascites/serum ratio were significantly higher than benign ascites group. Difference were statistically significant （all P 〈0.05）. Combined detection＇s sensitivity and accuracy was the best, in which the sernm＇s sensitivity was 75.7% and accuracy was 82.3%. Ascites sensitivity was 89.0% and accu- racy was 91.3%. [ Conclusions] Ferritin and CA125 combine detection for differentiating benign and malignant as- cites has great value.Worthy of recommended for clinical applications.