乌司他丁辅助全身麻醉对慢性阻塞性肺疾病患者血清炎症因子水平的影响

Effect of Ulinastatin auxiliary general anesthesia during laparoscopic surgery on COPD patients' serum TNF-α, IL-6, IL-8 levels and clinical significance

目的分析乌司他丁辅助全身麻醉对慢性阻塞性肺疾病(COPD)患者接受腹腔镜手术时血清TNF-α、IL-6、IL-8水平的影响及其临床意义。方法选择在本院接受腹腔镜手术治疗的胆囊结石伴COPD患者作为研究对象,随机分为接受常规全身麻醉的对照组以及接受乌司他丁辅助全身麻醉的观察组,比较两组患者的气道峰压、炎症因子水平、肾功能等差异。结果观察组患者接受乌司他丁辅助全身麻醉后的各个时间段气道峰压都明显低于对照组患者(P<0.05)。观察组患者术中及术后1d的血清TNF-α、IL-6、IL-8水平均明显低于对照组患者(P<0.05)。观察组患者接受乌司他丁辅助麻醉后的各个时间段BUN、Cr水平均明显低于对照组患者(P<0.05)。结论乌司他丁辅助全身麻醉可以有效降低COPD腹腔镜手术患者的气道峰压,降低炎症因子水平,优化肾功能指标。

[ Objective] To analysis effect of Ulinastatin auxiliary general anesthesia during laparoscopic surgery on COPD patients＂ serum TNF-ct, IL-6, IL-8 levels and clinical significance. [ Methods ] 86 cases of patients with COPD received laparoscopic surgery were chose as the research object, randomly divided into control group with conventional general anesthesia, and observation group with ulinastatin auxiliary general anesthesia. Airway peak pressure, inflammatory factor levels and renal function were compared. [Results] Airway peak pressure each time after general anesthesia in observation group were significantly lower than that in control group （P 〈0.05）. The intra- operative and postoperative serum TNF-ct, IL-6, IL-8 levels in observation group were significantly lower than that in control group（P 〈0.05）. The patients in observation group after accepting ulinastatin auxiliary anesthesia every pe- riod of BUN and Cr levels were significantly lower than that in control group （P 〈0.05）. [Conclusions] Ulinastatin auxiliary general anesthesia can effectively reduce the laparoscopic surgery in patients with COPD airway peak pres- sure, reduce levels of inflammatory factors, optimize renal function indexes.