黄精调节糖代谢的活性及作用机理研究进展

Advances in studies of glucose regulation activities,mechanisms of Polygonatum sibiricum Red.

黄精是滋肾润肺和补脾益气的常用中药。近年来发现黄精对糖尿病及其并发症有明显预防和治疗作用。作用机制研究表明,黄精对糖尿病性胰岛素异常、调节葡萄糖转运蛋白的表达、抗炎、肝细胞内c AMP的含量降低、氧化损伤、小肠酶活性降低等方面均有较好的治疗作用,同时一定程度延缓糖尿病并发症的发生和发展。本文按抗糖尿病作用机制对黄精进行分类和归纳,并提出了开发利用黄精的建议:将滇黄精中的主要活性成分群(总皂苷及总多糖)及主要活性单体成分开发成具有辅助调节血糖水平的药品、保健品或健康食品。

Medicinal plant Polygonatum sibiricumhas funtions of nourishing kidney and lungs and invigorating spleen and replenishing qiIt is commonly used in traditional Chinese medicinePSibiricum showed extensive application in the prevention and treatment of diabetes and its complicationsAnti diabetic mechanisms of these medicinal plants may included the regulation of abnormal insulin，expression and regulation of glucose transporter，antiinflammatory effect，alternation of intracellular content of cAMP in liver cells，alleviation of oxidative damage and regulation of intestinal enzyme activitiesMoreover，it could delay the occurrence and development of diabetes and its complicationsThis paper reviewed the glucose regulation activities and mechanisms of PsibiricumFurthermore，some suggestions on its development and utilization were provided in this reviewThe main active component of Pkingianum（total saponins and total polysaccharides）and the main active component monomer could be developed as drugs for blood glucose regulation and or health food