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基于代谢组学的脓毒症实验研究进展 被引量：1

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摘要 脓毒症是危重病医学面临的棘手难题,也是危重病人死亡的主要原因。临床检测具有一定的滞后性,利用代谢组学对脓毒症患者进行早期预测,及时治疗以减少其死亡率具有重要意义。
作者 马军宏 侯艳婷 杨秀竹 于向阳 周振理
机构地区 天津中医药大学 天津市南开医院 天津国际生物医药联合研究院中药新药研发中心
出处 《中国中西医结合外科杂志》 CAS 2014年第6期664-666,共3页 Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词 脓毒症 代谢组学 生物标记物
分类号 R631 [医药卫生—外科学]
  • 相关文献

参考文献16

  • 1Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sep- sis in the United States from 1979 through 2000 [J]. N EngI J Med, 2003, 348(16): 1546-1554.
  • 2Fiehn O. Combining genomic3, metabolome analysis, and biochemi- cal modelling to understand metabolic networks [J]. Comp Funet Genomics, 2001, 2(3) :155-168.
  • 3Pham-Than H, Kaskavelis L, Dnaykin CA, et al. Method develop- ment in high-performance liquid chromatography for high-through- put Profiling and metabonomic studies of biofluid samples [J]. J Chromatogr B:Analyt Technol Biomed Life Sei, 2003, 789(2): 283-301.
  • 4Shoekeor JP, Holmes E. Metabonomic applications in toxicity screening and disease diagnosis [J]. Curt Top Med Chem, 2002, 2 (1): 35-51.
  • 5任成山.脓毒症的发病机制[J].中国急救医学,2005,25(10):748-750. 被引量：36
  • 6魏西军.盲肠结扎穿刺法大鼠脓毒症模型的复制[J].西部医学,2012,24(7):1243-1244. 被引量：6
  • 7赵金锋,罗进,刘世宾,李钢.盲肠结扎穿刺致大鼠脓毒症的模型改良[J].浙江中西医结合杂志,2008,18(10):605-606. 被引量：7
  • 8孟海兵,许平波,许华,邓小明,林中营,严诗楷,李金宝.应用代谢组学技术早期预测脓毒症大鼠的预后[J].中华急诊医学杂志,2009,18(2):120-126. 被引量：4
  • 9Lin ZY, Xu PB, Yan SK, et al. A metabonomic approach to early prognostic evaluation of experimental sepsis by (1)H NMR and pat- tern recognition [J]. NMR Biomed, 2009, 22(6): 601-608.
  • 10Li Y, Liu H, Wu X, et al. An NMR metabolomics investigation of perturbations after treatment with chinese herbal medicine formula in an experimental model of sepsis [J]. OMICS, 2013, 17(5): 252-258.

二级参考文献22

  • 1朱雪琦,刘清泉,姚咏明.脓毒症动物模型制备方法的研究进展[J].中国危重病急救医学,2006,18(2):114-116. 被引量：30
  • 2汤耀卿,李磊.脓毒症动物模型制作方略及应用[J].中华实验外科杂志,2006,23(12):1433-1434. 被引量：59
  • 3Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care[J]. Crit Care Med, 2001, 29(11 ): 1303- 1310.
  • 4Povoa P, Coelho L, Almeida E, et al. C-reactive protein as a marker of infection in critically ill patients[J]. Clin Microbiol Infect, 2005, 11 (2) : 101-108.
  • 5Castelli GP, Pognani C, Meisner M, et al. Procalcitonin and C-reactive protein during systemic inflamtoatory response syndrome, sepsis and organ dysfunction[J]. Crit Care, 2004, 8(2): 234-242.
  • 6Osuchowski MF, Welch K, Siddiqui J, et al. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality[J]. J Immunol, 2006, 177(3): 1967- 1974.
  • 7Dajak M, Ignjatovic S, Majkie-Singh N, et al. Prognostic value of phospholipase A2 group Ⅱ, C-reactive protein and Simplified Acute Physiological Score Ⅱ in intensive care patients[J]. Clin Lab, 2006, 52 (7 - 8):387-392.
  • 8Sponholz C, Sakr Y, Reinhart K, et al. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature[J]. Crit Care, 2006, 10(2) :145.
  • 9Jones GL, Sang E, Goddard C, et al. A functional analysis of mouse models of cardiac disease through metabolic profiling[ J]. J Biol Chem, 2005, 280(9): 7530-7539.
  • 10Wichterman KA, Bane AE, Chandry IH. Sepsis and septic shock-a review of laboratory models and a proposal[J]. J Surg Res, 1980, 29 (2) : 189-201.

共引文献49

同被引文献47

  • 1白丽红,徐克前.炎症性疾病早期诊断的新指标—sTREM-1[J].国际病理科学与临床杂志,2007,27(1):73-76. 被引量：8
  • 2Dellinger RP,Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock,2012[J]. Intensive Care Med,2013,39(2):165-228.
  • 3Van den Bruel A, Haj-Hassan T, Thompson M, et al. Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries : a systematic review[J]. Lancet,2010,375(9717):834-845.
  • 4Craig JC,Williams GJ, Jones M,et al. The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15781 febrile illnesses[J/OL]. BMJ,2010,340: c1594(2010-04-20)[2015-12-14]. http://www. bmj. com/content/340/ bmj. cl594. long.
  • 5Van den Bruel A, Thompson MJ, Haj-Hassan T, et al. Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review[J/OL]. BMJ,2011,342: d3082. http://www. bmj. com/content/342/bmj. d3082. long.
  • 6Hisamuddin E, Hisam A, Wahid S,et al. Validity of C-reactive protein (CRP)for diagnosis of neonatal sepsis[J]. Pak J Med Sci,2015,31(3):527-531.
  • 7Yo CH,Hsieh PS, Lee SH, et al. Comparison of the test characteristics of procalcitonin to C-reactive protein and leukocytosis for the detection of serious bacterial infections in children presenting with fever without source: a systematic review and meta-analysis[J]. Ann Emerg Med,2012,60(5):591-600.
  • 8Henry BM, Roy J, Ramakrishnan PK, et al. Procalcitonin as a Serum Biomarker for Differentiation of Bacterial Meningitis From Viral Meningitis in Children: Evidence From a Meta- Analysis[J], Clin Pediatr(Phila) ,2015 Sep 15.[Epub ahead of print].
  • 9Bustos BR,Padilla PO. Predictive value of procalcitonin in children with suspected sepsis[J]. Rev Chil Pediatr,2015,86(5):331-336.
  • 10Kim KE,Han JY. Evaluation of the clinical performance of an automated procalcitonin assay for the quantitative detection of bloodstream infection[J]. Korean J Lab Med,2010,30(2):153-159.

引证文献1

二级引证文献5

中国中西医结合外科杂志
2014年 第6期

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