细胞周期依赖性激酶抑制蛋白和激酶抑制蛋白及其与口腔疾病

Cyclin-dependent kinase inhibitor protein and kinase inhibitor protein and oral diseases

细胞周期和程序性细胞死亡与口腔疾病的发生发展密切相关,细胞周期蛋白、细胞周期依赖性激酶(CDK)、细胞周期依赖性激酶抑制剂是与细胞周期调控有关的主要分子。细胞周期依赖性激酶抑制蛋白(CIP)和激酶抑制蛋白(KIP)由P21、P27和P57三种蛋白质构成,参与细胞周期和程序性细胞死亡调控,抑制多种CDK的活性。口腔疾病的大多数组织破坏是由病变刺激因素诱导宿主细胞增殖和程序性细胞死亡异常改变所引起的,而CIP和KIP表达降低或缺失则导致牙龈结合上皮组织明显增厚,白斑伴上皮异常增生,肿瘤细胞增殖失控;因此,CIP和KIP在调控牙龈上皮细胞增殖和维持牙周组织的正常功能活动中起着不可替代的作用,其表达水平和活性可作为预测口腔白斑恶变与否,肿瘤进展和预后的重要指标。本文就CIP和KIP的组成和功能,CIP和KIP与口腔疾病等研究进展作一综述。

Cell cycle and programmed cell death are closely related to the development of oral diseases. Cyclins, cyclindependent kinase（CDK）, and cyclin-dependent kinase inhibitor are the major important moleculars for the regulation of cell cycle. Cyclin-dependent kinase inhibitor protein（CIP） and kinase inhibited protein（KIP） are constituted by P21, P27, and P57, which are involved in regulating cell cycle, cell death programming, and inhibiting the activity of CDK. Most of the tissue destruction of oral disease is caused by pathogens that disturb host cell proliferation and programmed cell death. The reduced or absent expression of CIP and KIP leads to junctional epithelium thickening, leukoplakia with epithelial dysplasia, and uncontrolled proliferation of tumor cells. Therefore, CIP and KIP plays an irreplaceable role in the regulation of gingival epithelial cell proliferation, the maintenance of periodontal tissues, and the expression level and activity of their work as an important target of canceration of oral leukoplakia and the progression and prognosis of tumors. This article focuses on the composition and function of CIP and KIP and the relationship between CIP-KIP and oral disease.