卵巢癌与相关分子转移机制的研究进展

Research Progress on Ovarian Cancer and Its Related Molecular Metastatic Mechanism

卵巢癌是死亡率最高的妇科肿瘤。由于早期症状不明显,多数患者发现时已是晚期,而晚期患者缺乏有效的治疗方案,其5年生存率不到40%。约70%卵巢癌患者伴有广泛的腹膜转移,一旦发生了转移,卵巢癌患者的预后将大大下降。所以卵巢癌转移的发病机制研究成为亟待解决的问题,该文就目前国内外关于卵巢癌转移的研究进展作一综述。

Ovarian cancer has the highest mortality among gynecologic cancer. Ovarian cancer＇s lethality primarily stems from the inability to detect the disease at an early, organ-confined stage, and the lack of effective therapies for advanced disease. Indeed,despite treatment improvements, the majority of women continue to present at advanced stages with a 5-year survival rate of less than 40%. Most of patients have developed to the late stage when diagnosed. Approximately 70% of patients with advanced stage ovarian cancer have widespread metastases, including the formation of malignant serous effusion. When metastasis occurs, ovarian cancer is currently incurable. So there is a need for a better understanding of the mechanisms of metastasis of ovarian cancer. This article mainly reviews on the research progress on the metastasis of ovarian cancer.