宫颈腺样基底细胞癌16例报告

Cervical adenoid basal carcinoma:report of 15 cases

目的：探讨宫颈腺样基底细胞癌（ABC）的临床、病理特点及鉴别诊断。方法：采用组织学及免疫组织化学方法对16例ABC进行观察、分析。结果：ABC临床症状不明显,妇科检查宫颈无明显异常或轻度糜烂;活检组织学检查常合并宫颈高级别鳞状上皮内瘤变（CIN3）或宫颈管黏膜原位腺癌（AIS）。行宫颈锥切或单纯子宫切除术。镜下：瘤细胞体积较小,形态一致,排列紧密,细胞质少,胞核深染,核分裂不活跃;呈小巢状、条索状在宫颈间质内浸润性生长,巢周围细胞呈栅栏状排列,部分细胞巢中央见腺腔样结构及鳞状分化,无明显间质反应。浸润深度2-7mm,宽度3-7mm。随访1-8年无异常发现。病理诊断：宫颈腺样基底细胞癌。结论：ABC常伴有CIN3和AIS,诊断应与腺样囊性癌（ACC）等宫颈肿瘤相鉴别。

Objective：To investigate the cervix adenoid basal carcinoma clinical,pathological features and differential diagnosis.Methods：To observe and analyze 16 cases of adenoid basal carcinomar by tissue and immunohistochemistry methods and reviewd pertinent literatures.Results：The clinical symptoms of cervical adenoid basal carcinoma was not obvious;Gynecological examination of cervical no abnormal or mild erosion;Biops-y：Often companion with CIN3 or AIS.For conization of cervix or simple hysterectomy.Histological examination ：Tumor cells with small volume,Cell morphology consistent,Closely packed,Less cytoplasm,With hyperchromatic nuclei,Nuclear fission was not active.A small nests,Cords and invasive growth in cervical stroma.Around the nest cells palisading,Part of the cell nests appeared adenoid structure and squamous differentiation.Stromal reaction was not obvious.The depth of invasion 2-7mm,3-7mm width.Follow up 1-8years,No abnormal findings.Pathologic diagnosis：Cervical adenoid basal carcinoma.Conclusion：ABC often companion with CIN3 or AIS,To diagnose and differential diagnosis of cervix neoplasms is adenoid cystic carcinoma.