复发性卵巢癌患者放疗联合热疗的临床观察

Clinical Observation on Radiotherapy Combined with High Frequency Thermotherapy for Recurrence Ovarian Cancer Patients

目的:探讨热疗联合放疗在复发性卵巢癌治疗中的协同增敏作用。方法:68例晚期复发性卵巢癌患者,将其随机分为单纯放疗组(对照组)和热疗联合放疗组(实验组)。两组盆腔三维适形放疗单次剂量为200 c Gy,1次/日,5次/周。实验组在放疗结束后2小时内进行热疗,2次/周,共5周。治疗前及治疗结束后1个月均通过超声及CT检查对两组患者肿瘤体积的变化进行疗效评估,同时观察两组患者治疗后3年的生存情况。结果:近期疗效中发现,实验组11例完全缓解,17例部分缓解,对照组3例完全缓解,15例部分缓解,两组总有效率及完全缓解率差异均有统计学意义(P<0.05)。实验组3年总的生存率明显高于对照组,差异有统计学意义(P<0.05)。结论:热疗联合放疗可有效的杀灭复发的卵巢恶性肿瘤细胞,可缓解放疗副反应,明显提高患者的生存率。

Objeetive： To investigate the sensitizer and mitigate adverse effects of thermal therapy adjuvant radiotherapy in the treatment of recurrent ovarian cancer. Methods： 68 advanced （Ⅲ, Ⅳ period） ovarian cancer patients were randomly divided into radiotherapy alone group （control group） and radiotherapy combined with hyperthermia group （experimental group）. Two groups of patients were treated with pelvic three-dimensional conformal radiotherapy by single dose of 200 cGy, 1 time per day, 5 times per week. Hyperthermia was conducted in the experimental group 2 hours after the end of radiotherapy, 2 times per week, in total 5 weeks. Before and after treatment for 1 months, the clinical efficacy was evaluated by the changes of tumor volume using ultrasonic and CT examination. The incidence of adverse reactions during treatment and survival condition 3 years after surgery were observed and compared. Results： The difference in the total effective rate and tumor complete remission rate between two groups was statistically significant （P〈0.05）. Three year survival rate of the experimental group was significantly higher than that of the control group, and the difference was significant difference （P〈0.05）. Conclusions： Radiotherapy combined with high frequency thermotherapy could effectively kill the remaining and recurrence of the tumor cells, improve the survival rate, reduce the side effects of radiation, so as to improve the quality of life.