心力衰竭患者血浆可溶性晚期糖基化终末产物受体(sRAGE)变化与心功能的关系

Relationship between plasma sRAGE and heart function in patients with heart failure

目的：探讨心力衰竭患者血浆可溶性晚期糖基化终末产物受体（soluble receptor for advanced glycation endproducts, RAGE）浓度变化,分析 sRAGE 与心功能的关系。方法选择首都医科大学附属北京同仁医院就诊的心力衰竭患者,纽约心脏学会（New York Heart Association,NYHA）心功能分级为Ⅱ~Ⅳ级,同期住院非心力衰竭患者为对照组,用酶联免疫吸附测定法方法定量检测血浆 sRAGE 浓度,对比分析各组间血浆 sRAGE 浓度的差异。结果血浆 sRAGE 浓度在对照组为（0.562±0.473）ng/mL,心力衰竭组为（0.844±0.705）ng/ mL,2组间比较差异有统计学意义（P〈0.01）。血浆 sRAGE 浓度在 NYHAⅡ级组为（0.680±0.506）ng/ mL、NYHAⅢ级组（0.844±0.646）ng/ mL、NYHAⅣ级组（91.077±0.910）ng/ mL。各组间比较差异有统计学意义（P〈0.05）。结论心力衰竭患者血浆 sRAGE 水平升高,且与心力衰竭的严重程度相关。

Objective To investigate the level of soluble receptor for advanced glycation endproducts（sRAGE） in patients with heart failure, to analyze the relationship between sRAGE and heart function. Methods Select 100 patients with heart failure treated in our hospital（NYHA Ⅱ-Ⅳ）, at the same time collect 50 cases hospitalized without heart failure, record general condition, and use the ELISA method to detect the levels of plasma sRAGE, applied SPSS 16. 0 software to carry on statistical analysis. Results The plasma sRAGE level was increased in patients with heart failure than the control group, showing a significant difference（P〈0. 01）. Plasma sRAGE level in the control group was（0. 562 ± 0. 473） ng/ mL, in the heart failure group was（0. 844 ± 0. 705） ng/ mL. With the cardiac function classification increased, plasma sRAGE level was elevated also, the control group was（0. 562±0. 473）ng/ mL, NYHAⅡ level group was （0. 680±0. 506）ng/ mL, NYHAⅢ level group was（0. 844 ±0. 646） ng/ mL, NYHAⅣ level was（1. 077 ±0. 910） ng/ mL. there is a significant difference （ P = 0. 004）. The plasma level of sRAGE had negative correlation with LVEF in patients with heart failure. Conclusion The plasma level of sRAGE was elevated in patients with heart failure, the level of plasma sRAGE and severity degree of heart failure present a associated relationship, with NYHA heart function classification increased, the plasma sRAGE level was elevated too.