基于Pubmed数据库的前部缺血性视神经病变文献计量分析

Bibliometric analysis of current AION research based on Pubmed database

目的了解近20年国内外前部缺血性视神经病变(AION)相关文献的分布规律和研究热点。设计文献计量学分析研究。研究对象1994年1月至2013年12月Pubmed数据库所收录的AION相关文献。方法以Pubmed数据库为数据源,对1994年1月至2013年12月所收录的AION相关文献进行统计分析,采用多元统计方法对高频主题词共现矩阵进行转换并进行类聚分析和绘制战略坐标图;根据社会网络分析方法绘制可视化网络图谱。主要指标基于高频主题词及副主题词的聚类分析、战略坐标图分析和社会网络分析。结果共检出AION相关文献1599篇,近20年来每年发文量变化不大。美国、英国、德国、法国4个发达国家总发文量1232篇,占发文总数的77%,中国以18篇文献排名第11。通过对55个高频主题词或副主题词进行聚类分析,结果显示当前的热点主要集中在以下11个领域:(1)AION的发病年龄、危险因素、遗传等病因及视觉障碍、盲的病因。(2)AION视觉障碍、盲诊断及视神经系统疾病诊断和鉴别诊断。(3)AION视觉障碍及视神经病理生理并建立疾病模型探讨该病发病机制和AION、视神经、视盘、视网膜神经节细胞病理学。(4)该病需做视敏度、视野、眼底、眼压检查。(5)AION及巨细胞动脉炎的并发症。(6)AION和巨细胞动脉炎药物疗法及AION的预防与控制。(7)AION的化学诱导及磷酸二酯酶抑制剂副作用。(8)视神经系统检查常用辅助检查如荧光素眼底血管造影、磁共振成像、超声波检查等。(9)回顾性和前瞻性研究方法。(10)AION视神经的血液供给及代谢和视敏度、视野的生理。(11)AION的外科学及手术后并发症。战略坐标图和社会网络分析显示:AION病因、诊断、病理生理较成熟。病因研究在AION中处于核心地位,与疾病的诊断、治疗等领域有着密切关系;AION在基因研究及治疗上研究相对薄弱,有较大的提升空间。结论多元统计和社会网络分析,直观展示了20年国内外AION研究现状、热点和趋势。欧美国家在AION研究领域起着主导作用。国内相关研究的国际影响力有待加强。

Objective To survey the distribution pattern and subject domain knowledge of worldwide anterior ischemic optic neuropathy （AION） researches based on literatures in Pubmed database. Design Biblionmetric analysis. Participants Literatures on AION published in 1994 to 2013 were identified in Pubmed database. Methods Literatures on AION published in 1994 to 2013 were i- dentified in Pubmed database. The analytic items of an article include published year, country language and journal. After core mesh terms had been characterrized by Bibliographic item co-ocurrence matrix builder （BICOMS）, the co-occurrence matrix was built. Cluster analysis was finished by SPSS20.0. Then visualized network was drawn using Ucinet 6.0. Main Outcome Measures Cluster analysis, social network analysis and the visualized knowledge mapping based on high-frequency subjects. Results Totally 1599 literatures were included, the number of annual articles changed slightly between 1994 and 2013. The United States, England, Germany and France to- gether accounted for 77% of articles. There were 55 high-frequency subjects and hot topics were cluster into the following 11 categories： （1） AION caused of aged, risk factors and visual disorders, as well as blindness. （2） Diagnosis of AION visual disorder and optic ne- oropathy, as well as differential. （3） Pathology and physiopathology of AION, visual disorder, nerve and disk, as well as disease models. （4） Examination of visual acuity, visual fields, fundus oculi and intraocular pressure. （5） Complications of AION and giant cell arteritis. （6） Drug therapy of AION and giant cell arteritis, as well as AION prevention and contral. （7） Chemically induced of AION and adverse effects of phosphodiesterase inhibiters includs of piperazines, purines and sulfones. （8） Methods of nerve system examinations including fluorescein angiography, megnetic resonance imaging and uhrasonography. （9） Methods of restrspective and prospectives studies. （10） Metabolism and blood supply of AION optic nerve, as well as the physiology of visual acuity and visual fields. （11） Surgery and other postoperative complications of AION. The visualized domain knowledge mapping was successful built. The etiology and risk factors in the core domain, which have an important link to diagnosis and therapy. The researches on AION gene, drug therapy were not devel- oped well, which was of great promotion space. Conclusions The distribution pattern and subject domain knowledge of worldwide AION researches in the recent twenty years were shown by using bibliometric analysis. Western developed countries play a leading role in the field of AION research, which needs to be strengthened in China.