肝硬化患者食管静脉曲张破裂出血的影响因素

Risk factors of esophageal variceal bleeding in patients with hepatic cirrhosis

目的分析肝硬化患者食管静脉曲张破裂出血(esophageal variceal bleeding,EVB)发生的相关危险因素。方法回顾分析2007年1月至2012年12月肝硬化合并EV的患者的临床资料,分为出血组(n=216)和对照组(n=182),统计分析EVB发生的危险因素。结果出血组和对照组之间门静脉内径、食管静脉曲张程度、红色征、Child-Pugh分级及血小板计数(platelet count,PLT)差异均存在统计学意义(P<0.05),其中门静脉内径、食管静脉曲张程度、红色征、Child-Pugh分级与EVB呈正相关,而PLT则与EVB呈负相关。结论门静脉内径、食管静脉曲张程度、红色征、Child-Pugh分级及PLT均为肝硬化EVB的危险因素。

Objective To investigate the risk factors of esophageal variceal bleeding（ EVB） in patients with hepatic cirrhosis. Methods The clinical data of 398 patients with hepatic cirrhosis admitted from January 2007 toDecember 2012 were retrospectively analyzed,including216 patients with EVB（EVB group） and 182 without EVB（control group）. The risk factors of EVB were analyzed with non-conditional Logistic regression. Results There was significant difference in the diameters of the portal vein,the classification of varicosis,red wale sign,level of Child-Pugh and platelet count（PLT）between the EVB group and control group. The EVB was positive correlated with the diameters of the portal vein,the classification of varicosis,red wale sign,level of Child-Pugh,but negatively correlated with the PLT. Conclusion The diameters of the portal vein,the classification of varicosis vein,red wale sign,level of Child-Pugh and PLTare risk factors of EBV in patients with hepatic cirrhosis.