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SIRT1与血液系统肿瘤关系的研究进展 被引量：2

Research progress on SIRT1 and hematologic neoplasm
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摘要 SIRTl(silent mating-type information regulation 2 homologue 1)是一种组蛋白去乙酰化酶,通过对底物的去乙酰化修饰,参与细胞的生理、病理过程,进而影响多种疾病的发生发展。SIRT1参与血液系统肿瘤的发生,并表现出促进和抑制的双重作用,这可能与肿瘤的类型及其复杂的上下游信号通路有关。SIRT1及其通路有望为复发、难治血液系统肿瘤的治疗提供一条新的途径。 Silent mating-type information regulation 2 homologue 1（ SIRT1） is a kind of histone deacetylase,which is involved in cell function and pathophysiological process by deacetylation of substrates. It is proved that SIRT1 participates in tumorigenesis and exhibits dual functions as a tumor promoter or suppressor,dependent on the tumor type and its complex signaling pathways. SIRT1 is expected toprovide a new approach for treatment of refractory and relapsed hematologic neoplasm.
作者 李子卓 梁爱斌
机构地区 同济大学附属同济医院血液科
出处 《同济大学学报（医学版）》 CAS 2014年第5期124-127,共4页 Journal of Tongji University(Medical Science)
基金 国家自然科学基金(81270615)
关键词 SIRT1 肿瘤发生 血液系统肿瘤 SIRT1 tumorigenesis hematologic neoplasm
分类号 R733.7 [医药卫生—肿瘤]
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参考文献22

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同被引文献21

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同济大学学报（医学版）
2014年 第5期

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