糖尿病家族史和高血压与2型糖尿病患病风险性的关联分析

Correlation analysis of type 2 diabetes with diabetes family history and hypertension

目的探讨糖尿病家族史与高血压对2型糖尿病(T2DM)的发病是否存在交互作用。方法选取现场调查筛出的新发T2DM患者791例为病例组,以同期调查的血糖正常者4 374例为对照组,比较两组糖尿病家族史与高血压的患病率差异,运用相加模型分析糖尿病家族史和高血压在T2DM的发病中是否存在交互作用。结果病例组有糖尿病家族史的比例(χ2=40.13,P<0.001)和高血压患病率(χ2=120.35,P<0.001)均高于对照组。采用多因素非条件Logistic回归模型控制混杂因素后,糖尿病家族史与高血压共同存在对T2DM患病的协同效应指数为1.19,归因交互效应为0.52,归因交互效应百分比为12.2%,纯因子间归因交互效应百分比15.71%。结论糖尿病家族史与高血压对T2DM的发病有正交互作用,两者同时存在可增加罹患T2DM的危险性。

Objective To explore whether diabetes family history and hypertension have an interaction effect on the incidence of type 2 diabetes. Methods A total of 791 newly diagnosed patients with type 2 diabetes （T2DM） screened by our investigation were chosen as the case group, and 4 374 people with normal blood glucose in the same investigation were enrolled as the control group. The prevalence of diabetes family history and hypertension of the two groups were compared, and their correlation with T2DM was analyzed with an additive model. Results The prevalence of diabetes family history （X2 = 40. 1, P 〈 0. 001 ） and hypertension （X2 -- 145.4, P 〈 0. 001 ） of the case group were higher than those of the control group. After adjusting confounding factors by using a multiple Logistic regression mod- el, the synergy index was 1.19, the relative excess risk due to interaction was 0.52, the attributable interaction percent- age was 12.20%, and the pure attributable interaction percentage was 15.71%. Conclusion Diabetes family history and hypertension have a positive effect on the incidence of type 2 diabetes, and simultaneous existence of the two can lead to high risk of type 2 diabetes.