血清sCD25测定在肝细胞癌诊断中的意义

Significance of serum s CD25 level in diagnosis of hepatocellular carcinoma

目的:探讨血清s CD25水平在肝细胞癌(hepatocellular carcinoma,HCC)诊断中的意义.方法:本实验包括160例研究对象:40例HCC患者;40例肝硬化患者;40例慢性乙型病毒性肝炎(chronic hepatitis B,CHB)患者,40例健康志愿者.通过酶联免疫吸附方法(ELISA)测定每一受检者血清中s CD25水平.结果:HCC组血清s C D25水平(平均值=9641.23 pg/m L)显著高于肝硬化组、CHB组及健康对照组(P<0.05).在HCC的诊断中,s CD25比甲胎蛋白(alpha fetal protein,AFP)显示出更好的敏感性.结论:本实验表明,在早期H C C的检测中s CD25(95%C I:7584.47-11697.99 p g/m L)比A F P敏感性更高.有望作为HCC发生的一个新的预测指标并有可能用来区分早期HCC与晚期肝硬化.这正是国际社会目前研究的热点.

AIM： To explore the significance of serum s CD25 level in the diagnosis of hepatocellular carcinoma（HCC）.METHODS： A total of 160 subjects, including 40 patients with HCC, 40 patients with liver cirrhosis, 40 patients with chronic hepatitis B, and 40 healthy controls, were measured for serum s CD25 levels by enzyme-linked immuno sorbent assay（ELISA）.RESULTS： Serum s CD25 level in the HCC group（mean, 9641.23 pg/m L） was significantly higher than those in the cirrhosis group, chronic hepatitis B group and healthy control group（P 〈 0.05）. Serum s CD25 level demonstrated a better sensitivity than alpha fetal protein（AFP） in the diagnosis of HCC.CONCLUSION： Serum s CD25 level is effective in the detection of early HCC, and it may serve as a novel predictive marker of HCC to distinguish advanced cirrhosis from early HCC.