非霍奇金淋巴瘤与乙型肝炎病毒感染的关系

Relationship between non-Hodgkin's lymphoma and hepatitis B virus infection

目的:探讨乙型肝炎病毒(HBV)感染与非霍奇金淋巴瘤(NHL)发病的关系。方法:统计244例初发NHL患者HBV感染情况,并与228例同期门诊健康体检者进行比较。结果:244例NHL患者中,HBsAg阳性36例(14.75%);HBeAb和(或)HBcAb阳性共13例(5.33%);HBsAb阳性或阴性,其余4项均阴性共195例(79.92%)。而在228例健康体检者中,HBsAg阳性12例(5.26%);HBeAb和(或)HBcAb阳性共4例(1.75%);HBsAb阳性或阴性,其余4项均阴性共212例(92.98%)。NHL患者与健康体检者HBV感染情况比较,HBsAg阳性率、HBeAb和(或)HBcAb阳性率均差异有统计学意义(均P<0.05)。不同亚型NHL HBV感染情况也存在差异,以弥漫大B细胞淋巴瘤HBsAg阳性率最高,为22.22%(24/108),其他B细胞型淋巴瘤为14.29%(6/42),滤泡性淋巴瘤为11.11%(2/18),与健康体检者比较均差异有统计学意义(均P<0.05);而弥漫大B细胞淋巴瘤中HBeAb和(或)HBcAb阳性率为8.33%(9/108),其他B细胞型淋巴瘤为4.76%(2/42),滤泡性淋巴瘤为5.56%(1/18),与健康体检者比较亦差异有统计学意义(均P<0.05)。结论:NHL与HBV感染存在一定的相关性,尤其是弥漫大B细胞淋巴瘤。

Objective：To explore the association between non-Hodgkin＇s lymphoma（NHL）and hepatitis B virus（HBV）.Method：The positive rates of HBV infection were investigated in 244 patients of NHL and 228 cases of healthy controls.Result：The positive rates of HBsAg,HBeAb and（or）HBcAb in NHL patients were higher than those in healthy controls（P〈0.05）.In NHL patients,the positive rates of HBsAg,HBeAb and（or）HBcAb in DLBCL,B-cell and follicular lymphoma subtypes were respectively higher than those in healthy controls（P〈0.05）.Conclusion：There is association between HBV infection and NHL,especially in DLBCL.