急性早幼粒细胞白血病患者三氧化二砷维持治疗期间的血脂代谢特征分析

Serum lipid profile alterations in acute promyelocytic leukemia before and after arsenic trioxide therapy

目的:探讨三氧化二砷(ATO)维持治疗急性早幼粒细胞白血病(APL)时患者血脂代谢特征。方法:回顾性分析33例APL患者ATO维持治疗前、治疗第8天及第15天外周血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(Apo-A1)、载脂蛋白B(Apo-B)浓度变化。结果:与治疗前比较,APL患者治疗第8天TG值明显升高[(3.64±1.69)mmol/L∶(1.99±0.95)mmol/L,P=0.024],治疗第15天仍维持在较高水平[(3.51±1.77)mmol/L∶(1.99±0.95)mmol/L,P=0.042]。TC、HDL-C、LDL-C、Apo-A1和Apo-B五个脂类代谢指标在ATO维持治疗期间均未见明显变化(均P>0.05)。结论:ATO诱导治疗APL过程中,短期内血清TG水平升高,可能与ATO干扰肝脏内脂类代谢过程有关。

Objective：To explore the serum lipid profile alterations in acute promyelocytic leukemia（APL）before and after arsenic trioxide（ATO）therapy.Method：Retrospective analysis was performed on the clinical data of serum lipids from 33 hospitalized APL patients during ATO-maintaining therapy.The data were including serum total cholesterol（TC）,triglyceride（TG）,high density lipoprotein-cholesterol（HDL-C）,low density lipoproteincholesterol（LDL-C）,Apo lipoprotein A1（Apo-A1）and Apo lipoprotein B（Apo-B）,and were detected before,7days after and 14 days after initiating ATO,respectively.Result：TG levels were significantly increased for 7days and 14 days after initiating ATO than that before ATO therapy[（3.64±1.69）mmol/L vs（1.99±0.95）mmol/L,P=0.024;（3.51±1.77）mmol/L vs（1.99±0.95）mmol/L,P=0.042].There was no significance in the change of TC,HDL-C,LDL-C,Apo-A1 and Apo-B.Conclusion：Serum TG levels were increased limitedly in APL patients during ATO maintaining therapy.This may result from lipid metabolism abnormality in liver induced by ATO.