维甲酸受体α和β在胰腺癌组织中的表达及意义

Expression of retinoic acid recepter α and β in pancreatic cancer and its clinical significance

目的:探讨维甲酸受体-α、β在正常胰腺和胰腺癌组织中的表达及其临床意义,通过分析其表达了解维甲酸受体-α、β在胰腺癌发生发展中的作用。方法:采用免疫组织化学方法观察维甲酸受体-α、β在10例正常胰腺组织及30例胰腺癌组织中的表达情况,并分析其表达与胰腺癌临床病理特点之间的关系。结果:维甲酸受体-α在正常组织中的表达低于胰腺癌组织(P<0.05),在胰腺癌组织中随临床病理分期的升高表达量增加,并且随着肿瘤组织分化程度的降低,表达量增加(P<0.05),在远处转移和淋巴结转移的胰腺癌组织中的表达高于无转移组(P<0.05),但与患者年龄无关(P>0.05)。维甲酸受体-β在正常胰腺组织中的表达明显高于胰腺癌组织(P<0.05),在胰腺癌组织中的表达与临床病理分期、肿瘤组织分化程度及年龄无关(P>0.05),远处转移和淋巴结转移组中维甲酸受体-β的表达与未转移组差异亦无统计学意义(P>0.05)。结论:维甲酸受体-α和维甲酸受体-β与胰腺癌发生相关;维甲酸受体-α高表达提示预后不良;维甲酸受体-β在胰腺癌中起抑癌基因的作用。

Objective： To study the expression of retinoic acid recepter a and β（RAR- a andβ ）in normal pancreatic tissue and pancreatic cancer and its clinical significance. To understand the role of RAR- a, β in occurrence and development of pancreatic cancer through analyzing its ex- pression. Method： The expression of RAR-a and βin the samples from 10 cases of normal pancreatic tissues and 30 cases of pancreatic cancer tissues was detected by using immunohisto- chemical method, and the relationship between RAR- a and β expression and the clinicopathologi- cal characters of pancreatic caneer was analyzed. Results： The expression of RAR-a in normal pancreatic tissue was inferior to in pancreatic cancer tissues（P〈 0.05）. RAR- a expression was in- creased with the increase of surgery clinical pathologic stage and histological grades in pancreatic cancer tissues（P 〈 0.05）. RAR-a expression of metastasis and lymph node metastasis was higher than no metastasis in pancreatic cancer tissues（P〈 0.05）, but its expression was unrelated to age （P 〉 0.05）. The expression of RAR-β in normal pancreatic tissue was higher than in pancreatic cancer tissues （P 〈 0.05）. RAR- β expression was unrelated to clinical pathologic stage, histological grades and age in pancreatic cancer tissues（P〉 0.05）. There was no statistically differences of RAR- β expression between metastasis or lymph node metastasis groups and no metastasis groups in pan- creatic cancer tissues. Conclusion： RAR- a and β is related to the occurrence of pancreatic can- cer. The high expression of RAR- a prompt the poor prognosis in pancreatic cancer. RAR- β plays the role of cancer suppressor gene in pancreatic cancer.