黏附分子与川崎病发病机制关系的研究进展

Advances in research of the relationship between adhesion molecules and pathogenesis of Kawasaki disease

黏附分子(AM)是介导细胞与细胞间或细胞与基质间相互作用的一类分子总称,通过配体-受体相结合的形式参与细胞间识别、信号转导、细胞增殖与分化、细胞伸展与运动,是免疫应答、炎症发生、凝血、肿瘤转移、创伤愈合等一系列生理病理过程的分子基础。川崎病(KD)是一种急性全身中、小血管炎性综合征,主要累及冠状动脉,是儿童后天获得性心脏病的主要原因之一。研究AM与KD发病机制的关系对了解KD发病机制、预防及治疗KD心血管系统并发症有积极作用。

Adhesion molecules （AM） are a class of molecules that can mediate cell-to-cell and cell-to-matrix interaction. They participate in the cellular recognition, signal transduction, cell proliferation and differentiation, cell stretching and movement through ligand-to-receptor interaction. AM are the molecular basis of immune response, inflammation, blood coagulation, tumor metastasis, wound healing and a series of physiological and pathological processes. Kawasaki disease （KD） is an acute systemic small vasculitis syndrome, mainly affecting coronary artery. KD is the main cause for acquired heart disease in children. To study the relationship between AM and pathogenesis of KD is important in the understanding of KD pathogenesis, prevention and treatment of coronary artery lesions complicated with KD. This review focused on the relationship between AM and pathogenesis of KD.