摘要
m RNA处理小体,又称P-小体(processing bodies,P-bodies),是细胞质中含有多种功能蛋白和RNA的聚集体.评述P-小体的形成和运动特点,以及其与小RNA、外切体相互作用,参与基因表达的调控.介绍了本实验室在P-小体植物细胞中的最新研究进展.指出P-小体是m RNA降解和储存的场所,在转录后水平参与基因表达的调控,P-小体在细胞中是动态变化的,P-小体中多样化的功能蛋白在P-小体的组装、功能行使中发挥重要作用.P-小体作为细胞质内m RNA的储存和降解结构在基因表达的转录后调控中起重要作用,其调控机制尚待进一步研究补充,P-小体与小RNA分子(micro RNA,mi RNA)调控的基因沉默之间也存在关联性.
mRNA processing bodies ( P-bodies ) are cytosolic aggregates containing a variety of functional proteins and RNAs. We briefly review the features of P-bodies formation and movement, the interaction of P-bodies with small RNAs and exosomes in the regulation of gene expression. We also summarize the latest P-bodies related research progress in our lab. P-bodies where mRNA degradation and storage take place play an important role in the posttranscriptional regulation of gene expression. They undergo dynamic changes inside the cell. A variety of functional proteins located in P-bodies are involved in the cytoplasmic assembly and biological functioning of P-bodies. The regulatory mechanism of P-bodies still needs to be investigated futher. P-bodies also participate in mi-croRNA( miRNA)-mediated gene silencing.
出处
《深圳大学学报(理工版)》
EI
CAS
CSCD
北大核心
2015年第1期48-57,共10页
Journal of Shenzhen University(Science and Engineering)
基金
国家自然科学基金资助项目(31210103901)~~