三苯氧胺对子宫内膜影响的声像图观察

The observation of sonographic features in endometrium effected by tamoxifen

目的通过超声观察乳腺癌术后长期服用三苯氧胺患者子宫内膜的变化及声像图特征。方法对2010年3月至2014年3月在我院门诊复查的38例乳腺癌术后长期服用三苯氧胺患者102次超声检查进行回顾分析。结果 38例乳腺癌术后服用三苯氧胺患者,分别于服药半年、1年、2年、3年及≥4年进行102次超声检查,超声下内膜变化:服药半年基本无明显增厚,服药1年后子宫内膜有不同程度改变,以内膜增厚、内膜息肉样病变、内膜小囊状改变为明显,尤其以散在分布的小囊状改变为特征。而且服药时间越长,改变越明显。结论长期服用三苯氧胺后子宫内膜病变发生率高,以内膜增厚、内膜息肉样病变及内膜小囊状改变为明显,特别是散在分布的小囊状改变为特征。阴道超声能清晰显示子宫内膜结构并准确测量内膜厚度,是目前评价子宫内膜的一种可靠实用的方法。

Objective To observe changes in endometrial and sonographic features of long-term use of tamox-ifen in patients with breast cancer after operation. Methods Thirty-eight patients with breast cancer after operation who long-term use tamoxifen with 101 ultrasound examinations were analyzed retrospectively. Results Thirty-eight cases of breast cancer in patients taking tamoxifen were in the medication for six months, a year, two years, three years and not less than four years respectively, and they were taken 102 ultrasound examinations. The endometrial of sonographic features were as follows. There was no significant thickening of the medication six months. There were different degrees of endometrial changes in intimal thickening, which were endometrial polypoid lesions, endometrial cystic change, especially the distribution of scattered small cystic changes after taking nearly a year characterized. And the longer taking medicine, the more obvious change of sonographic features in endometrium. Conclusion The high incidence of endometrial lesions appeared after long-term use of tamoxifen. The significant features are intimal thickening, endometrial polyps and endometrial lesions as small cystic change, especially in small scattered cystic changes in the distribution is characterized. Transvaginal ultrasound can clearly show the structure and measure en-dometrial thickness accurately, which is reliable and practical in evaluation of the endometrium.