阿尔茨海默病患者基于体素形态学的CT和磁共振影像的比较研究

A comparative study of voxel-based morphology CT and MR imaging for Alzheimer′s disease

目的探讨基于体素形态学的CT和磁共振(MR)影像对阿尔茨海默病(AD)患者的诊断价值。方法 AD患者和健康志愿者各5例,用3.0 T的扫描仪行MR检查,用3D矢状磁化预备快速梯度回波序列获取3D数据。1月后,所有参与者行正电子发射计算机断层显像(PET/CT)检查;然后静脉注射11C-PIB 600 MBq,并再次行PET/CT检查。完毕后,用统计参数图-8(SPM8)软件对MRI和PET/CT影像进行重建,并将两者进行比较分析。结果和志愿者相比,不管是MR还是PET/CT影像,AD患者两侧颞叶区域灰质均明显减少(P<0.001);与MR影像对比,PET/CT影像所示的变化区域更大。结论基于体素形态学的CT和MR影像均可对AD患者进行准确的诊断,但CT的敏感性更高。

Objective To evaluate the diagnostic value of voxel-based morphology（VBM） CT and MR imaging in Alzheimer′s disease （AD）. Methods Five cases of AD patients and the same number of normal volunteers were tested with a 3.0 T MR scanner, using 3D sagittal magnetization prepared rapid gradient echo sequence to obtain data. After one month, PET/CT examination was performed to acquire high quality scan;and then 600 MBq of 11C-PIB was given by intravenous injection, and the PET/CT examination was done again. Statistical parametric mapping-8 （SPM8） software was used for analysis of MR and PET/CT image. Results By comparation with volunteers, gray matter in both sides of the temporal lobe regions were significantly reduced in MR-VBM and CT-VBM of AD patients （P〈0.001） . Greater loss was observed in CT-VBM when it was compared with MR-VBM. Conclusion Both MR-VBM and CT-VBM were accurate for the diagnosis of AD patients, but CT-VBM was more sensitive than MR-VBM.