急性高眼压引起的视网膜功能改变及结构损伤研究进展

Retinal function change and structural damage induced by acute intraocular pressure elevation

急性眼压升高是视力损伤的重要危险因素.目前高眼压动物模型已证明眼压升高可引起视网膜结构与功能由内向外逐层损伤.急性高眼压主要通过机械压迫和导致的微循环缺血引起细胞微环境改变,最终诱导视网膜神经节细胞凋亡.不同眼压梯度及持续时间对视功能和组织结构的损伤程度不同,但具体量化指标尚无结论.现主要对急性高眼压对视功能与结构影响的研究进展进行综述.

Acute intraocular pressure （IOP） elevation is one of the key conditions responsible for visual dysfunction.Several animal models have demonstrated that elevated IOP gradually induces retinal structure and function damage from the inside to the outside.Mechanical compression and ischemia contribute to the alteration of the cellular microenvironment,which eventually cause the apoptosis of retinal ganglion cells.Different levels and duration of IOP result in different degrees of functional and structural damage.This article reviews the progress in current research about the influence of acute IOP elevation on visual function and structure.