247例血液病患者经验性抗感染治疗药物分析

Analysis of empirical anti-infective therapy to 247 cases with hematologic diseases

目的分析某院血液内科住院患者抗感染药物应用情况,为血液病经验性抗感染治疗提供参考。方法采用回顾性分析方法,随机抽取247份血液内科出院患者病例,分析病原菌分布、经验性抗感染治疗及抗菌药物应用情况。结果血液内科住院患者中发热患者占27.1%,中性粒细胞减少患者占25.5%,行经验性抗感染治疗患者占91.3%;感染以革兰阴性菌为主,真菌感染率较高;抗感染治疗以头孢菌素类、喹诺酮类及抗真菌药物应用最多。结论血液病患者易发生院内感染,经验性抗感染治疗对疾病的控制非常重要,同时亦应加强细菌培养并根据药敏结果选择最佳治疗方案。

Objective To investigate the antibacterial application in hematologic diseases treatmens ,and provide reference to empiric anti‐infective therapy .Methods A retrospective analysis was performed and 247 discharged patients of hematology diseases were randomly selected .The pathogen distribution ,empiric anti‐infective therapy and antibacterial drugs application were analyzed . Results Hematology fever patients accounted for 27 .1% ,neutropenic patients accounted for 25 .5% ,and empiric anti‐infective therapy patients accounted for 91 .3% .Main patients infected by G - bacterial and fungal infections rate was high .The antibacte‐rial drugs were mainly cephalosporin ,quinolones and antifungal .Conclusion Patients with blood diseases were prone to have nos‐ocomial infections and empiric anti‐infective therapy was very important .We should strengthen the bacterial culture work and se‐lect the optimal treatment regimen based on susceptibility results .