双黄升白颗粒在慢性丙型病毒性肝炎抗病毒治疗中升白细胞作用的临床研究

Clinical Observation of Shuanghuang Shengbai Granule in Increasing Leukocyte Effect in Antiviral Therapy of Chronic Hepatitis C

目的探讨双黄升白颗粒预防性治疗慢性丙型病毒性肝炎干扰素抗病毒治疗所致白细胞计数减少的临床疗效。方法选取2011年6月—2013年6月河南省中医院收治的慢性丙型病毒性肝炎患者62例,采用随机数字表法分为治疗组32例,对照组30例,分别于干扰素治疗开始同时服用双黄升白颗粒(15 g/次,3次/d)和利血生(20mg/次,3次/d),然后检测每组患者治疗前,治疗后2、4、8周外周血白细胞计数、中性粒细胞计数及骨髓抑制情况。结果两组治疗前后白细胞计数和中性粒细胞计数比较,差异均有统计学意义(P<0.05);治疗方法与治疗时间存在交互作用(P<0.05);组间比较,差异有统计学意义(P<0.05);时间间比较,差异有统计学意义(P<0.05)。对照组22例(73.3%)患者发生骨髓抑制,其中轻度14例、中度6例、重度2例;治疗组12例(37.5%)患者发生骨髓抑制,其中轻度9例、中度2例、重度1例。对照组骨髓抑制发生率高于治疗组(χ2=10.980,P=0.011)。结论双黄升白颗粒预防性用药对于治疗干扰素所致白细胞计数减少较利血生效果好,同时所致骨髓抑制发生率更低,双黄升白颗粒是一种安全有效的预防干扰素所致白细胞计数减少的有效药物。

Objective To observe the effect of Shuanghuang Shengbai granule in preventive treatment for interferon induced leucopenia in patients with chronic hepatitis C. Methods 62 patients with chronic hepatitis C treated in Henan Traditional Chinese Medicine Hospital from June 2011 to June 2013 were randomly divided into treatment group（31 cases）and control group（30 cases）. The two groups were given Shuanghuang Shengbai granule（15 g a time,three times per day）and Leucogen（20 mg a time,three times per day）. The peripheral white blood cells count,neutrophil count and bone marrow suppression were detected before treatment,two weeks,four weeks and eight weeks after treatment. Results The white blood cells count and neutrophil count before and after treatment between the two groups both showed statistically significant differences （P ﹤ 0. 05）. There was interaction between treatment and time（ P ﹤ 0. 05）. The inter - group difference was statistically significant（P ﹤ 0. 05）,and the time showed statistically significant difference（P ﹤ 0. 05）. 22 cases（73. 3% ）in the control group had bone marrow suppression,with 14 slight level cases,6 moderate level cases and 2 severe level cases;12 cases （37. 5% ）in the treatment group had bone marrow suppression,with 9 slight level cases,2 moderate level cases and one severe level case. The control group had higher incidence of bone marrow suppression than the treatment group（ χ2 = 10. 980,P =0. 011）. Conclusion Shuanghuang Shengbai granule has good effect with leucogen in preventing leukopenia induced by IFN, and it is a safe,cheap and convenient drug to treat leucopenia induced by IFN.